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Disease Data for CLCNKA

Basic Information

Gene Taxonomy:
CLCNKA
UniprotID:
P51800
Mouse Homolog:
Clcnkb ,Clcnka
Pharos Link:
Pharos Link
Knockout Mouse Phenotype:
decreased renal glomerular filtration rate
premature death
Hydronephrosis
Hypokalemia
Hyperchloriduria
Hypotension
Hypermagnesiuria
Polyuria
Failure to thrive
Adipose tissue loss
Hyperprostaglandinuria
Abnormal bone structure
Increased blood urea nitrogen
Abnormality of urine homeostasis
Hypochloremia
Alkalosis
Increased urinary potassium
Hypovolemia
Increased circulating renin level
decreased bone mineral content
decreased body length
decreased grip strength
improved glucose tolerance
shortened QRS complex duration
increased lean body mass
small kidney
increased fasting circulating glucose level
hearing/vestibular/ear phenotype
renal/urinary system phenotype
decreased urine osmolality
decreased physiological sensitivity to xenobiotic
dilated distal convoluted tubules
alkalemia
juxtaglomerular cell hyperplasia
abnormal distal convoluted tubule morphology
abnormal juxtaglomerular apparatus morphology
abnormal kidney blood vessel morphology
abnormal renal transport
increased urine sodium level
abnormal kidney afferent arteriole morphology
abnormal loop of Henle ascending limb thick segment morphology
abnormal renal sodium ion transport
abnormal kidney efferent arteriole morphology
Polyuria
increased susceptibility to induced colitis
decreased urine osmolality
Monogenic Disease Association:
Bartter disease type 4B
Polygenic Disease Association:
hypertensive disease
10K Immunome:
Not Detected
SARS-CoV-2 Association:
Not Detected
SARS-CoV-2 Vaccine Association:
Not Detected
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Exploring the Dark Genome