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Data and Resources for CACNA2D2 Gene

Disease Associated Data

Basic Information

Gene Taxonomy:
CACNA2D2
UniprotID:
Q9NY47
Mouse Homolog:
Cacna2d2
Pharos Link:
Pharos Link
Knockout Mouse Phenotype:
Purkinje cell degeneration
hindlimb paralysis
premature death
impaired coordination
Abnormal neuron morphology
decreased body size
Impaired proprioception
reduced fertility
abnormal axon morphology
Seizures
abnormal neuron physiology
decreased neuron number
decreased survivor rate
Gait disturbance
abnormal ventral spinal root morphology
nervous system phenotype
decreased Purkinje cell number
decreased spinal cord size
abnormal spike wave discharge
abnormal Purkinje cell morphology
Tremor
abnormal locomotor behavior
abnormal motor capabilities/coordination/movement
abnormal heart rate
abnormal involuntary movement
limb grasping
Decreased body weight
Abnormal motor neuron morphology
Abnormality of the pituitary gland
Abnormal myelination
Abnormality of the spinal cord
Absence seizures
Abnormal enzyme/coenzyme activity
Hypoplasia of the thymus
Cerebellar dysplasia
Failure to thrive
Bradycardia
Dehydration
Abnormal eating behavior
Cerebellar vermis hypoplasia
Female infertility
Myoclonus
Abnormal nervous system electrophysiology
Lethargy
Ataxia
Abnormality of the medulla oblongata
Rhinitis
Abnormality of movement
abnormal hindbrain development
no abnormal phenotype detected
postnatal lethality
incomplete penetrance
abnormal CNS synaptic transmission
absent corpus luteum
endocrine/exocrine gland phenotype
small cerebellum
reduced male fertility
reduced female fertility
reproductive system phenotype
tonic seizures
abnormal spinal cord white matter morphology
behavioral arrest
decreased brain weight
increased susceptibility to pharmacologically induced seizures
abnormal brain wave pattern
decreased neurotransmitter release
abnormal neuromuscular synapse morphology
abnormal uterus morphology
abnormal vertebral column morphology
abnormal thymus involution
induced hyperactivity
abnormal miniature endplate potential
abnormal spinal nerve morphology
short vertebral body
abnormal sexual interaction
abnormal miniature inhibitory postsynaptic currents
abnormal glial cell physiology
axonal dystrophy
skeletal muscle hypoplasia
abnormal CNS glial cell morphology
absent lactotrophs
abnormal dorsal spinal root morphology
decreased pons size
Abnormality of hindbrain morphology
Monogenic Disease Association:
Not Detected
Polygenic Disease Association:
absence epilepsy
epileptic encephalopathy
10K Immunome:
Not Detected
SARS-CoV-2 Association:
Not Detected
SARS-CoV-2 Vaccine Association:
Not Detected

Constructs for Lentiviral Expression

Basic Information

Gene Taxonomy:
CACNA2D2
Virus Type:
Lentiviral Vector
Vector Type:
cDNA
Construct ID:
IDG_CACNA2D2_OE_1

Selection:
Amp, Blasticidin

Vector:
lPX304

Construct Type:
Expression

Tag:
C terminal V5

Passed QC:
Yes

Sequence

Inserted_sequence:
ATGGCGGTGCCGGCTCGGACCTGCGGCGCCTCTCGGCCCGGCCCAGCGCGGACTGCGCGCCCCTGGCCCGGCTGCGGCCC
CCACCCTGGCCCCGGCACCCGGCGCCCGACGTCCGGGCCCCCGCGCCCGCTGTGGCTGCTGCTGCCGCTTCTACCGCTGC
TCGCCGCCCCCGGCGCCTCTGCCTACAGCTTCCCCCAGCAGCACACGATGCAGCACTGGGCCCGGCGTCTGGAGCAGGAG
GTCGACGGCGTGATGCGGATTTTTGGAGGCGTCCAGCAGCTCCGTGAGATTTACAAGGACAACCGGAACCTGTTCGAGGT
ACAGGAGAATGAGCCTCAGAAGTTGGTGGAGAAGGTGGCAGGGGACATTGAGAGCCTTCTGGACAGGAAGGTGCAGGCCC
TGAAGAGACTGGCTGATGCTGCAGAGAACTTCCAGAAAGCACACCGCTGGCAGGACAACATCAAGGAGGAAGACATCGTG
TACTATGACGCCAAGGCTGACGCTGAGCTGGACGACCCTGAGAGTGAGGATGTGGAAAGGGGGTCTAAGGCCAGCACCCT
AAGGCTGGACTTCATCGAGGACCCAAACTTCAAGAACAAGGTCAACTATTCATACGCGGCTGTACAGATCCCTACGGACA
TCTACAAAGGCTCCACTGTCATCCTCAATGAGCTCAACTGGACAGAGGCCCTGGAGAATGTGTTCATGGAAAACCGCAGA
CAAGACCCCACACTGCTGTGGCAGGTCTTCGGCAGCGCCACAGGAGTCACTCGCTACTACCCGGCCACCCCGTGGCGAGC
CCCCAAGAAGATCGACCTGTACGATGTCCGAAGGAGACCCTGGTATATCCAGGGGGCCTCGTCACCCAAAGACATGGTCA
TCATCGTGGATGTGAGTGGCAGTGTGAGCGGCCTGACCCTGAAGCTGATGAAGACATCTGTCTGCGAGATGCTGGACACG
CTGTCTGATGATGACTATGTGAATGTGGCCTCGTTCAACGAGAAGGCACAGCCTGTGTCATGCTTCACACACCTGGTGCA
GGCCAATGTGCGCAACAAGAAGGTGTTCAAGGAAGCTGTGCAGGGCATGGTGGCCAAGGGCACCACAGGCTACAAGGCCG
GCTTTGAGTATGCCTTTGACCAGCTGCAGAACTCCAACATCACTCGGGCCAACTGCAACAAGATGATCATGATGTTCACG
GATGGTGGTGAGGACCGCGTGCAGGACGTCTTTGAGAAGTACAATTGGCCAAACCGGACGGTGCGCGTGTTTACTTTCTC
CGTGGGGCAGCATAACTATGACGTCACACCGCTGCAGTGGATGGCCTGTGCCAACAAAGGCTACTATTTTGAGATCCCTT
CCATCGGAGCCATCCGCATCAACACACAGGAATATCTAGATGTGTTGGGCAGGCCCATGGTGCTGGCAGGCAAGGAGGCC
AAGCAGGTGCAGTGGACCAACGTGTATGAGGATGCACTGGGACTGGGGTTGGTGGTAACAGGGACCCTCCCTGTTTTCAA
CCTGACACAGGATGGCCCTGGGGAAAAGAAGAACCAGCTGATCCTGGGCGTGATGGGCATTGACGTGGCTCTGAATGACA
TCAAGAGGCTGACCCCCAACTACACGCTTGGAGCCAACGGCTATGTGTTTGCCATTGACCTGAACGGCTACGTGTTGCTG
CACCCCAATCTCAAGCCCCAGACCACCAACTTCCGGGAGCCTGTGACTCTGGACTTCCTGGATGCGGAGCTAGAGGATGA
GAACAAGGAAGAGATCCGTCGGAGCATGATTGATGGCAACAAGGGCCACAAGCAGATCAGAACGTTGGTCAAGTCCCTGG
ATGAGAGGTACATAGATGAGGTGACACGGAACTACACCTGGGTGCCTATAAGGAGCACTAACTACAGCCTGGGGCTGGTG
CTCCCACCCTACAGCACCTTCTACCTCCAAGCCAATCTCAGTGACCAGATCCTGCAGGTCAAGTATTTTGAGTTCCTGCT
CCCCAGCAGCTTTGAGTCTGAAGGACACGTTTTCATTGCTCCCAGAGAGTACTGCAAGGACCTGAATGCCTCAGACAACA
ACACCGAGTTCCTGAAAAACTTTATTGAGCTCATGGAGAAAGTGACTCCAGACTCCAAGCAGTGCAACAACTTCCTTCTG
CACAACCTGATCTTGGACACGGGCATCACGCAGCAGCTGGTAGAGCGTGTGTGGAGGGACCAGGATCTCAACACGTACAG
CCTACTGGCCGTGTTCGCTGCCACAGACGGTGGCATCACCCGAGTCTTCCCCAACAAGGCAGCTGAGGACTGGACAGAGA
ACCCTGAGCCCTTCAATGCCAGCTTCTACCGCCGCAGCCTGGATAACCACGGTTATGTCTTCAAGCCCCCACACCAGGAT
GCCCTGTTAAGGCCGCTGGAGCTGGAGAATGACACTGTGGGCATCCTCGTCAGCACAGCTGTGGAGCTCAGCCTAGGCAG
GCGCACACTGAGGCCAGCAGTGGTGGGCGTCAAGCTGGACCTAGAGGCTTGGGCTGAGAAGTTCAAGGTGCTAGCCAGCA
ACCGTACCCACCAAGACCAGCCTCAGAAGTGCGGCCCCAACAGCCACTGTGAGATGGACTGCGAGGTTAACAATGAGGAC
TTACTCTGTGTCCTCATTGATGATGGAGGATTCCTGGTGCTGTCAAACCAGAACCATCAGTGGGACCAGGTGGGCAGGTT
CTTCAGTGAGGTGGATGCCAACCTGATGCTGGCACTCTACAATAACTCCTTCTACACCCGCAAGGAGTCCTATGACTATC
AGGCAGCCTGTGCCCCTCAGCCCCCTGGCAACCTGGGTGCTGCACCCCGGGGTGTCTTTGTGCCCACCGTTGCAGATTTC
CTTAACCTGGCCTGGTGGACCTCTGCTGCCGCCTGGTCCCTGTTCCAGCAGCTTCTCTACGGCCTCATCTACCACAGCTG
GTTCCAAGCAGACCCCGCGGAGGCCGAGGGGAGCCCCGAGACGCGCGAGAGCAGCTGCGTCATGAAACAGACCCAGTACT
ACTTCGGCTCGGTAAACGCCTCCTACAACGCCATCATCGACTGCGGAAACTGCTCCAGGCTGTTCCACGCGCAGAGACTG
ACCAACACCAATCTTCTCTTTGTGGTGGCCGAGAAGCCGCTGTGCAGCCAGTGCGAGGCTGGCCGGCTGCTGCAGAAGGA
GACGCACTGCCCAGCGGACGGCCCGGAGCAGTGTGAGCTAGTGCAGAGACCGCGATACCGGAGAGGCCCGCACATCTGCT
TCGACTACAACGCGACAGAAGATACCTCAGACTGTGGCCGCGGGGCCTCCTTCCCGCCGTCGCTGGGCGTCCTGGTCTCC
CTGCAACTGCTGCTCCTCCTGGGCCTGCCGCCCCGGCCGCAGCCTCAAGTCCTCGTCCACGCCTCTCGCCGCCTC

Media and Files

Snapgene File:
D.IC2-pLX304-CACNA2D2-expression-vector.dna

Constructs for CRISPR Interference

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